천연식물추출물(RIP)이 쥐의 간섬유화 치료에 미치는 영향
(주)학지사
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- 2015.03.25
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- 2006.01
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서지정보
ㆍ발행기관 : 기초간호학회
ㆍ수록지정보 : 기초간호자연과학회지 / 8권 / 2호
ㆍ저자명 : 조수현
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구 방법
Ⅲ. 연구 결과
Ⅳ. 논의
Ⅴ. 결론 및 제언
참고문헌
영어 초록
Chronic liver diseases and hepatic cancer have been reported as 10% of cause of death in Koreans. Regardless of various causes, chronic liver disease accompanies commonly hepatic fibrosis. But still the mechanism of hepatic fibrosis remains poorly understood.
Using the dimethylnitrosamine(DMN)-induced hepatic fibrosis rat model, We performed to evaluate the possible therapeutic effect of RIP(extracts of Phellodendron amurense and Patrinia scabiosaefolia) and to investigate the changes in referential connective tissue proteins(TGF-β₁, α-smooth muscle actin, and vimentin) as a marker of fibrogenesis.
For these purposes, liver tissues were stained with H & E, and Azan staining for estimation of developing fibrosis. In the DMN-treated rat liver tissue, fibrosis were developed forming incomplete septal fibrosis. Whereas, in the RIP-treated rat liver tissues, the fibrosis were decreased recovering to normal morphology.
The expressions of TGF-β₁, α-smooth muscle actin(α-SMA), and vimetin were increased in the DMN-treated rat liver tissues, but decreased in the various areas of RIP-treated rat liver tissues.
According to these results, RIP could be a possible therapeutic agent to reduce hepatic fibrosis, and the TGF-β₁, α-SMA, and vimentin could be possible indicative markers of hepatic fibrosis development and recovery.
참고 자료
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