Long-Term Exposure of Sildenafil Citrate on Sperm Parameters in Rat

서지정보

ㆍ발행기관 : 한국동물번식학회 ㆍ수록지정보 : Reproductive & developmental biology / 35권 / 4호
ㆍ저자명 : Sekar Suresh, Elumali Prithiviraj, Nagella Venkatalakshmi, Mohanraj Karthik Ganesh, Lakshmanan Ganesh, Hyun-Jeong Lee, Seppan Prakash

목차

ABSTRACT INTRODUCTION MATERIALS AND METHODS Animal Used Sildenafil Citrate Administration SPERM ANALYSIS Sperm Count Sperm Viability and Motility Morphology and Morphometry Cytoplasmic Droplet Containing Sperm Analysis of Sperm Acrosomal Status Fertility Test RESULTS Sperm Analysis Morphology and Morphometrical Analysis Cytoplasmic Droplet Acrosomal Status Test Fertility Test DISCUSSION REFERENCES

영어 초록

Sildenafil citrate (SIL) a phosphodiesterase 5 inhibitor (PDE5I) has been used for long time as a first line oral drug for erectile dysfunction. Though it has beneficial effects on erectile organ it also has some adverse effects in other cells and/or tissues related to reproductive system when exposed to longer duration. The objective of the present study is to evaluate the long term effect of SIL on sperm parameters in Wistar albino rat. The animals are divided into two groups, for group I - rats were treated with saline (vehicle alone) and group - II oral administration of 5 mg/kg b.w. of SIL was administrated orally once in a day for 120 days. At the end of the trial period animals were sacrificed and epididymal sperm were subjected to various analysis. Results showed significant reduction in sperm count, motility, viability and morphologically intact sperm in long term PDE5I exposed animals when compared to control. Acrosomal status and fertility test also showed significant reduction in long term PDE5I exposed animals. The present study clearly indicated that long term SIL has shown to induce alteration in sperm quality and quantity, leading to decline in fertility rate. Indicate that SIL impinge on spermatogenesis as well as epididymal function. Understanding the molecular down-stream events involved in long-term exposure to PDE5 inhibitor can be valuable to supervise on related infertility issues and to suggest corrective measures.

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