獼猴桃根이 腎臟의 Natriuretic Peptide 系에 미치는 影響
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 한국전통의학연구소
ㆍ수록지정보 : 한국전통의학지 / 14권
ㆍ저자명 : 김경아, 금경수, 이시형, 황우준, 이호섭, 유인식
ㆍ저자명 : 김경아, 금경수, 이시형, 황우준, 이호섭, 유인식
영어 초록
The present study was undertaken to evaluate the antagonistic effects of water extracts of Chinese gooseberry (Actinidia chinensis P.) root on the natriuretic peptide receptor system in the rat kidney. By using in vitro receptor autoradiography, specific 125I-atrial natriuretic peptide (125I-ANP) binding sites were localized in glomerulus, inner medulla, intrarenal artery, vasa recta bundle, and renal pelvis of Sprague Dawley rat kidney. These specific bindings were competitively displaced by water extracts of Chinese gooseberry root in a dose dependent manner. Also, productions of 3',5'-cyclic guanosine monophosphate (cGMP) by activation of particulate guanylyl cyclase (GC) were stimulated by ANP in the glomerular and inner medullary membranes from rat kidney. These cGMP productions were inhibited by water extracts of Chinese gooseberry root in a dose dependent manner. The inhibitory effect of water extracts of Chinese gooseberry root on activation of GC was more potent rather than on 125I-ANP bindings to these renal structures. From affinity cross-linking study, the water extracts of Chinese gooseberry root inhibited the 125I-ANP labeling of GC-coupled natriuretic peptide receptor from renal glomerulus. Intravenous infusion of ANP elicits a potent diuresis, and urinary sodium andchloride excretions in New Zealand White rabbit. The pre-treatment of intravenous water extracts of Chinese gooseberry root infusion decreased competitively various renal effects of ANP with out changes in systemic hemodynamics. These results indicate that the water extracts of Chinese gooseberry root specifically inhibits the GC-coupled natriuretic peptide receptor subtypes (NPR-A), and suggest that the water extracts of Chinese gooseberry root may contain an antagonistic molecule regulating the biological functions of ANP system in the kidney and other organs.
참고 자료
없음"한국전통의학지"의 다른 논문
- 韓國産 樟科 植物에 관한 本草學的 硏究13페이지
- 腦血流및 血管에 미치는 옻나무의 效果10페이지
- 韓國産 薔薇科 植物에 관한 本草學的 硏究 Ⅰ39페이지
- 마우스 모델을 이용한 상백피 추출물의 알러지성 천식 억제 효과21페이지
- 梔子가 腎臟의 Natriuretic Peptide 系에 미치는 影響19페이지
- 丹田과 下腹部 經穴과의 상관성 硏究11페이지
- 뇌수막종의 MRI 소견 : 1예 보고6페이지
- 靈樞를 中心으로한 經絡 · 經穴의 診斷法 硏究14페이지
- 甘菊이 腦虛血에 미치는 影響17페이지
- 일부 자동차 공장 근로자들의 職業的 特性과 社會 心理的 Stress의 相關性 硏究16페이지