Identification of genomic regions associated with piglet survival and mortality
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 충북대학교 동물의학연구소
ㆍ수록지정보 : Journal of Biomedical Research / 15권 / 2호
ㆍ저자명 : Yoon-Jung Choi, Sang-Wook Kim, Joon-Ho Yoon, Bong-Hwan Choi, Tae-Hun Kim, Kwan-Suk Kim
ㆍ저자명 : Yoon-Jung Choi, Sang-Wook Kim, Joon-Ho Yoon, Bong-Hwan Choi, Tae-Hun Kim, Kwan-Suk Kim
영어 초록
One of the major problems in the modern pig industry is infectious disease. Susceptibility to infectious diseases is influenced by both constitutional (e.g. genotype, age, gender, and reproductive status) and environmental factors (e.g. nutrition, management, infections, and other forms of stress). Genetic variations within individual animals or herds can cause differences in the execution of immune functions against infectious agents in domestic pigs. The objectives of the present study were to identify genetic factor(s) responsible for piglet survival and mortality under commercial field conditions with infectious diseases as well as determine QTL regions for immune capacity in a pig reference family. Sex ratio was examined between normal grown and presumed dead groups of F2 animals generated by Korean native pigs (KNP) and Yorkshire (YS) breeds. The ratio of males was significantly higher in the presumed dead group than in the normal grown group. In order to study genetic factors associated with presumed mortality under disease outbreak, allelic frequencies of 239 single nucleotide polymorphisms (SNPs) were compared between normal grown and presumed dead groups. Exactly 22 SNPs showed significant differences in their allelic frequencies between the two groups, and four of them were validated with another commercial population divided by normal and emaciated pigs. Furthermore, the relationships between 239 SNPs and immune-related traits were studied. These results demonstrate that identification of genetic components of animal immune systems and susceptibility to infectious diseases is possible and will be useful to improve disease resistance in individuals as well as in breeding programs.참고 자료
없음"Journal of Biomedical Research"의 다른 논문
- Azidothymidine and recombinant human interferon-alpha t..4페이지
- Evaluation of biocompatibility of α-1,3 galactosyltrans..6페이지
- Unilateral noncystic renal dysplasia in a Sprague Dawle..4페이지
- Promotional effects of Sargassum fusiforme fractions on..6페이지
- Association between carotid intima-media thickness and ..4페이지