구강편평세포암종에서 Snail과 E-cadherin의 면역조직화학적 발현

서지정보

ㆍ발행기관 : 대한구강악안면병리학회 ㆍ수록지정보 : 대한구강악안면병리학회지 / 33권 / 1호
ㆍ저자명 : 유미현, 육종인, 김남희, 고현석, 백정미, 박정국, 이상휘, 김수아, 김현실

목차

I. 서론
II. 재료 및 방법
1. 연구 대상
2. 연구 방법
3. 통계 처리
III. 연구 결과
1. 연구 대상자의 임상적 특징
2. 면역조직화학염색 결과
IV. 고찰
V. 결론
VI. 참고문헌

영어 초록

Epithelial-mesenchymal transition (EMT) can play an important role in carcinogenesis of oral squamous cell carcinoma (OSCC). EMT is characterized by morphological and phenotypical change of epithelial cells into mesenchymal cells, and transcriptional repressor of E-cadherin, Snail is critical for EMT. In order to investigate the role of Snail and E-cadherin in OSCC, we analyzed the immunohistochemical pattern of Snail and E-cadherin in 18 OSCCs. The expression of Snail in the OSCC was increased whereas the expression of E-cadherin in the OSCC was decreased in comparison with those of normal oral mucosa, showing reverse correlation. Especially, the fibroblasts near the islands of OSCC showed the positivity of Snail, suggesting the reactive fibroblasts to the EMT of epithelial tumor cells. In metastatic squamous cell carcinoma in cervical lymph node, the positivity of Snail of tumor cells was higher than that of primary OSCC. We concluded that the increased Snail expression and the decreased E-cadherin expression were involved in the progression, invasion and metastasis of OSCC.

참고 자료

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