치자 열매로부터 추출한 topoisomerase I 효소 저해제의 구조 동정과 활성에 관한 연구
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서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 36권 / 4호
ㆍ저자명 : 고영종, 최창우, 임원봉, 김지선, 김상우, Sandeep Karna, Zeng Hui, 전상미, 조민성, 최홍란, 김옥준
ㆍ저자명 : 고영종, 최창우, 임원봉, 김지선, 김상우, Sandeep Karna, Zeng Hui, 전상미, 조민성, 최홍란, 김옥준
목차
Ⅰ. IntroductionⅡ. Material and Method
1. Plant material extraction
2. Topoisomerase I inhibition assay
3. Open column chromatography
4. High-performance liquid chromatography analysisand preparation
5. Structural elucidation
6. MTT assay
7. Histomorphologic evaluation by Diff-QuickⓇstaining
8. Caspase-8, 9 and caspase-3 activity assay
9. Immunoblotting
Ⅲ. Results
1. Topoisomerase I inhibitory activity of Gardeniajasminoides Ellis by extracts using varioussolvents
2. Dichloromethane extract of Gardenia jasminoidsEllis separation using by open column fraction
3. High performance liquid chromatograpy in 90 %and 100 % methanol open column fraction ofGardenia jasminoids Ellis
4. Structural analysis of topoisomerase I inhibitorin Gardenia jasminoids extract
5. Topoisomerase I inhibition acitivity of linoelaidicacid
6. Effects on cell viability of linoelaidic acid inHaCaT and FaDu cells.
7. Caspase-8, 9 and -3 activity assay of linoelaidicacid
8. LC3 protein expression by linoelaidic acidstreatment
Ⅳ. Discussion
Ⅴ. References