The Immunoexpression of Visfatin in Oral Carcinogenesis from Korean Patients
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 39권 / 2호
ㆍ저자명 : Se-Ra Park, Hye-Yeon Han, Jiyeon Kim, Moon-Kyoung Bae, Mi Heon Ryu, Soo-Kyung Bae
ㆍ저자명 : Se-Ra Park, Hye-Yeon Han, Jiyeon Kim, Moon-Kyoung Bae, Mi Heon Ryu, Soo-Kyung Bae
목차
<AbstractⅠ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
1. Patients and tissue specimens
2. Immunohistochemical stain for visfatin
3. Evaluation of immunohistochemical stain
4. Statistical Analysis
Ⅲ. RESULTS
1. Immunohistochemical stain for visfatin
2. Correlation between visfatin and the clinicopathologicalparameters of OSCC patients
3. Correlation between visfatin and NF-kB p65 inOSCC patients
IV. DISCUSSION
V. REFERENCES
영어 초록
Visfatin is a pro-inflammatory cytokine, which is thought to play a central role in systemic inflammation and the pathogenesis of obesity related diseases. Only a few studies investigated the effect of visfatin on human cancers. Furthermore, there have been no studies on the association between the expression of visfatin in OSCC tissue and its effect on OSCC patients. Hence, the present study analyzed the expression of visfatin in OSCC from Korean patients. Immunohistochemistry for visfatin was performed using 12 normal oral mucosas (NOM), 16 oral leukoplakias (with/without dysplasia), and 58 OSCC patients samples. Immunoreactivity was semi-quantitatively scored and the correlation between the expression of visfatin and clinicopathological parameters of OSCC patients was analyzed. The immunohistochemical analysis demonstrated that the expression level of visfatin increased in OSCC alone (p<0.05). Moreover, the immunoexpression score of visfatin was significantly correlated with TNM stage of OSCC patients. Our findings suggested that visfatin can play a certain role in the pathogenesis of OSCC. In addition, visfatin was associated with the tumor progression of OSCC patients and may act as independent biomarker of OSCC.참고 자료
없음"대한구강악안면병리학회지"의 다른 논문
- 휘보10페이지
- 치성각화낭에서 발생한 법랑모세포종 - 증례보고 및 문헌고찰 -6페이지
- 석회화 낭성 치성종양과 법랑모세포 섬유치아종이 혼합된 치성종양4페이지
- 어린이의 이하선에서 발생한 망상형 신경섬유종 - 증례보고 및 문헌고찰 -8페이지
- 악하선 근방에 발생한 유표피낭 증례6페이지
- Developing a Monitoring System for Toothbrushing14페이지
- 세포부착 PHBV-교원질 나노섬유의 골유도재생 효용성 평가6페이지
- In vitro Apoptotic Effect of Terfenadine in Human Oral ..6페이지
- Molecular Surveillance of Staphylococcus aureus about V..10페이지
- 세포의 증식 및 냉동 보관을 위한 PHBV 나노 섬유막의 효용성 평가6페이지