A Role of Unsaturated Fatty Acid in Animal Reproductive Cells and Biology

서지정보

ㆍ발행기관 : 한국동물번식학회 ㆍ수록지정보 : Reproductive & developmental biology / 40권 / 2호
ㆍ저자명 : Yong Hwangbo, Hwa-Young Kim, Yu-Rim Lee, Seung Tae Lee, EunSong Lee, Hee-Tae Cheong, Boo-Keun Yang, Choon-Keun Park

목차

INTRODUCTION
UNSATURATED FATTY ACIDS ANDSPERMATOZOA
UNSATURATED FATTY ACID AND OOCYTEAND EMBRYO DEVELOPMENT
UNSATURATED FATTY ACIDS ANDREPRODUCTIVE EVENTS
Prostaglandin Synthesis
Steroid Synthesis
Follicle Development
CONCLUSION
REFERENCES

영어 초록

As a one of unsaturated fatty acid, polyunsaturated fatty acids (PUFAs) have multiple actions: as precursor of prostaglandins (PGs), steroid hormone synthesis and energy production in animal reproduction. PUFAs, which include omega-3 (n-3) and omega-6 (n-6), are derived from the diet and changed by diet, species, breed and season. The plasma membrane of spermatozoa in mammals contain various PUFAs. These composition of PUFAs regulate the membrane fluidity and cause lipid peroxidation via generation of reactive oxygen species (ROS). Induced lipid peroxidation by ROS decreased viability and motility of spermatozoa, and it is reduced by addition of antioxidant and low concentration of PUFAs. Because oocytes of animal have a high lipid components, process of oocyte maturation and embryo development are influenced by PUFAs. In in vitro study, oocyte maturation, embryo development, intracellular cAMP and MAPK activity were increased by treatment of n-3 α-linolenic acid (ALA) during maturation, whereas n-6 linoleic acid (LA) negatively influenced. Also, inhibition of fatty acid metabolism in oocyte influenced blastocyst formation of cattle. PGs are synthesized from PUFAs and various PUFAs influence PGs via regulation of PG-endoperoxide synthase (PTGS). Steroid hormone synthesis from cholesterol is regulated by expression of steroid acute regulator (StAR) protein and mRNA. Exogenous n-3 and n-6 PUFAs altered sex hormone in animal through stimulate or inhibit StAR activity. Because PUFAs altered PG and steroid hormone synthesis, follicular development was influenced by PUFAs. This effect of unsaturated fatty acid could provide information for improvement of reproductive ability in animals.

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