구강편평세포암종에서의 Ki-67과 p53의 발현 ; 구강내 원발성 편평세포암종과 림프절로 전이된 편평세포암종의 비교
(주)코리아스칼라
- 최초 등록일
- 2016.10.11
- 최종 저작일
- 2016.06
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서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 40권 / 3호
ㆍ저자명 : So-Young Choi, Jin-Wook Kim, Young-In Park, Sung-Min Kang, Su-Hyung Hong
목차
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS and METHODS
Patients and tissue sample
Immunohistochemistry
Statistical analysis
1. Clinicopathological characteristics
2. Immunohistochemical staining
Ⅲ. RESULTS
IV. DISCUSSION
V. REFERENCES
영어 초록
This study was performed to investigate the correlation between the primary squamous cell carcinoma in oral cavity (POSCC) and paired metastatic oral squamous cell carcinoma in cervical lymph node (MOSCC) via immunohistochemical staining with Ki-67 and p53. The subjects included ten patients (20 specimens) who were diagnosed with OSCC with metastatic lymph nodes from 2010 to 2015 and surgically treated involving neck dissection in Kyungpook National University Hospital. Twenty specimens were stained immunohistochemically with Ki-67 and p53. The degrees of immunostaining by Ki-67 and p53 was evaluated as 0 (no positive cells), weak (1~25% positive cells), moderate (26-50% positive cells) and strong (>50% positive cells). Despite the strong tendency, there was no statistically significant result between expressions of Ki-67 and p53 in POSCC or MOSCC. We found that high expression of Ki-67 was significantly correlated with poor degree of differentiation. Our results suggest that expression of Ki-67 may be a predictable factor for degree of differentiation of POSCC and MOSCC.
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