Effect of Acorus gramineus root water extract on the body adipose tissues

서지정보

ㆍ발행기관 : 충북대학교 동물의학연구소 ㆍ수록지정보 : Journal of Biomedical and Translational Research / 17권 / 3호
ㆍ저자명 : Sunhwa Hong, YeonShik Choi, Da-Seul Kim, Hye-Young Kwon, Okjin Kim

목차

Introduction
Materials and Methods
재료 및 추출
실험동물
군 구성
간 및 체내 지방 상대 장기 중량 측정
병리조직학적 검사
통계학적 방법
Results
간의 상대 장기 중량 및 NASH 변화
체내 지방 중량의 변화
간의 병리학적 검사
체내 지방조직의 병리학적 검사
Discussion
References

영어 초록

Acorus gramineus is a herb used frequently in oriental medicine. Clinically, the effects of Acorus gramineus are known as awakening of one’s consciousness, removal of sputum, and relief of autism. Experimentally, Acorus gramineus root(AGR)-induced cerebral blood flow increase depending on the concentration causes diverse responses of blood pressure and regional cerebral blood flow and possesses strong inhibitory effects of apoptosis in the nervous system. We investigated the effects of AGR water extract on the adipose tissue status. Male C57BL/6 mice were fed high fat diet and a total of 35 mice were divided into 5 groups: normal group, control group, and groups treated with AGR water extract at concentrations of 20, 100, and 500 mg/kg. The mice were treated by oral administration once a day for consecutive 6 weeks, and their weight changes were monitored. As the results, the groups treated with AGR water extract showed weight loss. Also, the weights of liver, epididymal fat, retroperitoneal fat and peri-renal fat were decreased in the groups treated with AGR water extract. In histopathological examination, the sizes of adipose tissues decreased in liver, epididymal fat, retroperitoneal fat, and peri-renal fat. These results indicate that AGR water extract have an anti-obesity activity, which could be used as an useful material to decrease body adipose tissues.

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