Allium victorialis leaf extract ameliorates DNCB-induced atopic dermatitis-like skin lesions in BALB/c mice

서지정보

ㆍ발행기관 : 한국예방수의학회(구 한국수의공중보건학회) ㆍ수록지정보 : 예방수의학회지 / 46권 / 2호
ㆍ저자명 : Hyeryeon Yang, Jong Bae Seong, Hyun Sik Yoon, Il Rae Rho, Du Hyeon Hwang, Euikyung Kim, Changkeun Kang

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Preparation of Allium victorialis leaf extract
Measurement of total polyphenol content
Reducing power assay
Experimental animals
Experimental study with AVE for AD mice
Measurement of ear thickness and organ weight
Histological analyses
Statistical Analysis
Results
Determination of total Polyphenol contents of AVEand its reducing power activity
AVE suppressed AD skin symptoms in DNCB-inducedmice
Histological analysis of DNCB-induced mice skin andear lesions
DISCUSSION
COMPETING INTERESTS
ACKNOWLEDGMENTS
REFERENCES

영어 초록

The leaves of Allium victorialis (AV) are known an edible perennial herb, which has been used in Korean traditional medicine. However, the beneficial pharmacological effects of AV extracts (AVE) on the antioxidant activity and atopic dermatitis (AD) have not been thoroughly examined. Therefore, the present study aims to investigate both antioxidant activity and anti-inflammatory effect of AVE on AD in vitro and in vivo. Antioxidant activity was evaluated by total polyphenol content and ferric reducing ability. AVE showed a level of polyphenol content and reducing power activity. The five-week-old BALB/c mice were used as an AD-like mouse model by treating them with 1-chloro-2, 4-dinitrobenzene (DNCB). Topical administration of AVE for 3 weeks to DNCB-treated mice significantly alleviated clinical skin lesion dermatitis severity and epidermal thickness. Histopathological analysis also demonstrated that AVE decreased eosinophil and mast cell infiltration into skin and ear tissue. These results suggest that topical application of AVE inhibits the development of AD-like skin lesion in mice by their antioxidant activity. Thus, AVE may be a potential therapeutic agent for AD.

참고 자료

없음