Bitter Taste, Rising New Functions and Significance of Extra-oral Expressions

서지정보

ㆍ발행기관 : 대한구강생물학회 ㆍ수록지정보 : International Journal of Oral Biology / 43권 / 3호
ㆍ저자명 : Su-Young Ki, Kyung-Nyun Kim

목차

Basic taste and bitter taste
T2Rs signaling pathway
Bitter taste receptors functions at the cellularlevel
Physiological roles of extra-oral T2Rs
Immunity
Secretion
Contraction of smooth/cardiac muscles.
Male reproduction and micturition
Polymorphisms of T2Rs
T2Rs and diseases.
Perspectives
References

영어 초록

Taste is closely related to intake of food. Taste perception is also influenced by type of food ingested, and nutrition and health status. Bitter taste plays an important role in the survival of human and animals to avoid probable toxic and harmful substances. Vertebrate animals recognize bitter taste through type 2 taste receptors (T2Rs). Several T2Rs have been expressed extra-oral such as the gastrointestinal tract, respiratory tract, urogenital tract, brain and immune cells, and parts of their functions are being revealed. This review will discuss physiological roles of T2Rs in relation to innate immunity, secretion and smooth muscle contraction expressed in extra-oral cells and tissues, and we summarize relationships between polymorphisms in T2Rs and general or oral diseases. It is not a coincidence that animals pay much genetic costs for taste and smell during evolution.

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