식품첨가물 E171이 수생물에 미치는 독성 평가
(주)코리아스칼라
- 최초 등록일
- 2023.04.10
- 최종 저작일
- 2023.03
- 13페이지/
어도비 PDF
- 가격 4,500원
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서지정보
ㆍ발행기관 : 한국환경생물학회
ㆍ수록지정보 : 환경생물 / 41권 / 1호
ㆍ저자명 : 송인규, 김강희, 윤학원, 박준우
목차
Abstract
1. 서 론
2. 재료 및 방법
2.1. E171의 물리화학적 특성 및 분산 안정성
2.2. 물벼룩/어류 노출시험
2.3. 생물체 내 ROS 측정
2.4. 산화스트레스 관련 유전자 및 효소 측정
2.5. 통계 분석
3. 연구 결과 및 고찰
3.1. E171의 물리화학적 특성 및 분산 안정성
3.2. 물벼룩/어류 노출시험
3.3. 생물체 내 ROS 형성
3.4. 산화스트레스 관련 유전자 발현 및 효소 활성
4. 결 론
적 요
사 사
REFERENCES
영어 초록
E171, a mixture of titanium dioxide, has been widely used as a food additive due to its whitening effect and low toxicity. However, it has been proven that E171 is no longer safe for public health. So far, there are insufficient studies on the toxic effects of E171 on organisms especially using standardized test methods. In this study, toxicity assessments of E171 to two aquatic species, water flea (Daphnia magna) and zebrafish (Danio rerio), were performed using modified standardized test methods based on the physicochemical properties of E171. The hydrodynamic diameter, polydispersity index, and turbiscan stability index (TSI) were measured to ensure the dispersion stability of E171 in exposure media during the test period. The EC50 for immobilization of water flea was 141.7 mg L-1 while zebrafish was not affected until 100 mg L-1 of E171. Measurements of reactive oxygen species (ROS) and antioxidant enzyme activities confirmed that E171 induced oxidative stress, leading to the activation of superoxide dismutase and catalase in both water flea and zebrafish, although the expression of antioxidant enzyme genes differed between species. These results suggested the potential risk of E171 to aquatic organisms and provided toxicological insights into the impacts of E171 on the environment.
참고 자료
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