자궁경부암-진단,staging,치료(RT포함)

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자궁경부암-진단,staging 및 예후,치료(RT포함)

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Epidemiology
Natural History and Pattern of Spread
Clinical Manifestations
Diagnosis

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Epidemiology (1)
Mean age :47 years(US), distribution bimodal (peaks ;35-39 yrs, 60-64 yrs)
US , 2003
12,200 new cases of invasive cervical cancer would be diagnosed
4100 patients were expected to die of cervical cancer;
1.6% of all cancer deaths in women
15% of deaths from gynecologic cancers
20-39 yrs women; second leading cause of cancer deaths (after breast cancer)
age-adjusted death rates declined
d/t the adoption of routine screening programs; pelvic examinations, cervical cytologic evaluation

Epidemiology (2)
HPV ;
Persistent infection: necessary for the development of CIN and invasive cancer
integration of HPV DNA into the human genome;
persistent transcription of the E6 & E7 genes
Functional inactivation of p53 (by E6 protein),Rb (by E7 protein)
disrupts normal cell-cycle control mechanisms

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