원발성 담관경화증, Primary billiary cirrhsis 2010
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- 2010.05.30
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- 2010.05
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소개글
2010 hepatology 에 기재된 원발성 담관경화증 Review article 요약본입니다.
목차
Definition
Epidemiology
Risk Factors
Inflammation
Cholestasis
Symptoms and Signsat initial presentation of PBC
Clinical courseIn early phase
Clinical courseIn Advanced phase
Differential diagnosis
PBC vs PSC
TREATMENT - Summery
Specific therapy
Specific therapy - UDCA
Specific therapies - Adjuvant
본문내용
Progressive immune-mediated destruction of the small intrahepatic bile ducts
Without treatment, progresses to cirrhosis and eventually liver failure over a period of 10-20 yrs.
Epidemiology
Incidence is 2.7 per 100,000 person years (4.5 women, 0.7 men)
Prevalence 65.4 per 100,000 women, 12.1 per 100,000 men.
Female predominant : F/M ratio - 9/1
The median age of disease onset 50 years but varies between 20-90 yrs.
Risk Factors
참고 자료
Harrison’s internal medicine, 17th, chapter302
Primary biliary cirrhosis, 2010 update Journal of Hepatology 2010 vol. 52 j 745–758
Primary biliary cirrhosis; Jayant A Talwalkar, Keith D Lindor; THE LANCET • Vol 362 • July 5, 2003
Primary biliary cirrhosis. Hepatology 2009;50:291–308.
EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol 2009;51:237–267.
Biochemical response to UDCA and long-term prognosis in primary biliary cirrhosis. Hepatology 2008;48:871–877