Ubiquitin & Ubiquitin Binding Domains
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- 2010.08.18
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소개글
ubiquitin과 binding domain에 대한 영어 ppt자료.
플래쉬 파일과 영어 스크립트 포함.
컴파일 실행환경
INTRODUCTION
FUNCTIONS OF UBIQUITIN
UBIQUITIN BINDING DOMAINS
CONCLUSIONS
본문내용
In 2004 three scientists got a Nobel Prize for their achievement about ubiquitin-mediated protein degradation.
Aaron Ciechanover, Avram Hershko and Irwin Rose, have contributed innovative chemical knowledge of how the cell can regulate the presence of a certain protein by marking unwanted proteins with a label consisting of the polypeptide ubiquitin. Proteins so labeled are then broken down rapidly in cellular "waste disposers" called proteasomes.
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참고 자료
Hicke, L. Schubert, H. L. and Hill, C. P. (2005) Ubiquitin-binding domains. Nat. Rev. Mol. Cell Biol. 6, 610–621
Hurley, J. H. Lee, S. and Prag, G (2006) Ubiquitin-binding domains. Rev. Biochem J. 399, 361-372
Aaron Cienchanover (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Rev. Mol. Cell Biol 6, 79-86
Debdyuti Mukhopadhyay and Howard Riezman (2007) Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling. Rev. Science 315, 201-205
Francois Bregegere, Yoram Milner, Bertrand Friguet (2006) The ubiquitin–proteasome system at the crossroads of stress-response and ageing pathways: A handle for skin care? Aging Res Rev 5, 60-90
Tony T. Huang and Alan D. D’Andrea (2006) Regulation of DNA repair by ubiquitylation. Rev. Mol. Cell Biol 7, 323-334
Francisco J. Herrera and Steven J. Triezenberg (2004) Molecular Biology: What Ubiquitin Can Do for Transcription. Current Biology 14, 622-624