Aptamer의 정의와 특징, 발전 구조, SELEX cycle전반적 내용

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Aptamer에 대한 정의와 특징, 발전 구조와 SELEX 과정에 관한 전반적인 내용을 실제교재와 논문의 Figure와 Table 그리고 입체 이미지를 통하여 알기 쉽게 표현 하였습니다. 66장의 슬라이드 하나하나가 알차고 실속있는 내용으로 organizing 하였으며, 대학생뿐만 아니라 대학원생의 과제자료로써 적합한 내용입니다.

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FIGURE 2 The levels of gene expression and corresponding target validation techniques.
FIGURE 3 Treatment with platelet-derived growth factor receptor (PDGFr) antagonists lowers interstitial fluid pressure in KAT-4 tumors. Tumor interstitial fluid pressure was measured 12 h after last administration of PDGF receptor inhibitor in KAT-4 tumors grown subcutaneously in severe combined immune deficiency (SCID) mice. PDGF receptor inhibitors were administered for a total of 4 days. A: Mice were treated with phosphate buffered saline (PBS) (n = 8) or STI571 (n = 9). B: Mice were treated with control aptamer (n = 8) or PDGF aptamer (n = 8). (Reproduced with permission from Pietras et al. Cancer Res 2002;62: 54765484.)
FIGURE 4 Treatment with PDGF receptor antagonists enhances the effect of Taxol on KAT-4 tumors in vivo. Growth curves of KAT-4 tumors grown subcutaneously in SCID
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