Induction of inflammatory Cytokines by a Keratin Mutation and their Repression by a Small Molecule in a Mouse Model for EBS
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- 2011.03.24
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Induction of inflammatory Cytokines by a Keratin Mutation and their Repression by a Small Molecule in a Mouse Model for EBS.
- EBS is a group of inherited disorders in which the skin blisters extremely easily. There are 3 main types of EBS. Each is a quite distinct disorder. If you have EBS then you cannot develop one of the other forms of EBS
목차
- Introduction
EBS
TNF-alpha
Keratine
-Backgrounds
-Result
R1
R2
R3
-Discussion
본문내용
EBS
EBS is a group of inherited disorders in which the skin blisters extremely easily. There are 3 main types of EBS. Each is a quite distinct disorder. If you have EBS then you cannot develop one of the other forms of EBS.
Tumor necrosis factor-alpha
Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction.
TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis, and viral replication.
TNF`s primary role is in the regulation of immune cells.
Keratine
Keratins are a family of fibrous structural proteins; tough and insoluble, they form the hard but nonmineralized structures found in reptiles, birds, amphibians and mammals. They are rivaled as biological materials in toughness only by chitin.
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