Primary Aldosteronism (원발알도스테론증, 일차알도스테론증)
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- 2011.11.03
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- 2011.11
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소개글
Primary Aldosteronism에 관한 발표 자료 입니다.
Primary Aldosteronism에 대해서 발표를 준비하거나 공부를 하시는 분께 도움이 되리라 생각합니다.
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Definition
A syndrome associated with hypersecretion of the aldosterone
primary aldosteronism : cause for the excessive aldosterone production resides within the adrenal gland
Cf) Secondary aldosteronism : stimulus is extraadrenal
Causes of Primary Hyperaldosteronism
Signs and symptoms
Most patients have diastolic hypertension
- due to the increased sodium reabsorption and extracellular volume expansion
- very severe & headaches
Potassium depletion (hypokalemia)
- muscle weakness, fatigue
- But, most with the bilateral hyperplasia type, may have potassium levels in the low normal range
no symptoms associated with hypokalemia.
Impairment of urinary concentrating ability
- polyuria, polydipsia.
Signs and symptoms
left ventricular enlargement
← secondary to the hypertension
electrocardiographic signs of hypokalemia
- prominent U waves, cardiac arrhythmias, premature contractions
edema is characteristically absent
Proteinuria may occur in as many as 50% of patients
& renal failure occurs in up to 15%.
(∵ structural damage to the kidney)
참고 자료
Jay L. Grosfeld et al: Pediatric surgery 6th edition: 2006: 628-639
Oldham: Principles and Practice of Pediatric Surgery, 4th Edition: 2005: chapter 42
Townsend : Sabiston textbook of surgery 18th edition e-book: 2008: chapter 39
Fauci : Harrison`s Principles of Internal Medicine, 17th edition: 2008: chapter 336