Syphilis (매독)

소개글

매독에 관한 레포트 자료 입니다.
매독에 대해서 발표를 준비하거나 공부를 하시는 분께 도움이 되리라 생각합니다.

목차

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본문내용

Definition
Chronic systemic infection caused by Treponema pallidum
Sexually transmitted disease
Incubation period averaging 2?6 weeks
→Primary lesion appears (chancre, regional lymphadenopathy 관련)
→Secondary stage (syphilid, generalized mucocutaneous lesions, lymphadenopathy)
→Latent syphilis
→Tertiary stage (치료하지 않은 환자의 1/3에서)

* Etiology
T. pallidum subspecies (distinguished primarily by the clinical syndromes they produce)
- pallidum : causes venereal syphilis
pertenue : causes yaws
endemicum : causes endemic syphilis or bejel
carateum : causes pinta
현재는 PCR을 통해서 각각을 구별할 수 있다. 그 외 Treponema subspecies들은 인간의 입, 위장관계, 생식기에서 발견된다.

T. pallidum : ttrilaminar cytoplasmic membrane에 싸인 가는 spiral organism
delicate peptidoglycan layer, lipid-rich outer membrane, Endoflagella 등으로 구성
in vitro에서 배양 불가능하여 1998년부터 균에 대한 정보가 알려지기 시작

참고 자료

Centers for Disease Control and Prevention: 2006 Sexually transmitted diseases treatment guidelines. MMWR 55:22, 2006
Centurion-Lara A et al: Gene conversion: A mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection. Mol Microbiol 52:1579, 2004 [PMID: 15186410]
Grassly NC et al: Host immunity and synchronized epidemics of syphilis across the United States. Nature 433:417, 2005 [PMID: 15674292]
Lukehart SA et al: Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med 351:154, 2004 [PMID: 15247355]
Marra CM et al: Cerebrospinal fluid abnormalities in patients with syphilis: Association with clinical and laboratory features. J Infect Dis 189:369, 2004 [PMID: 14745693]
??? et al: Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: Does HIV status matter? Clin Infect Dis 38:1001, 2004
Michelow IC et al: Central nervous system infection in congenital syphilis. N Engl J Med 346:1792, 2002 [PMID: 12050339]
Peeling R et al: Avoiding HIV and dying of syphilis. Lancet 364:1561, 2004 [PMID: 15519615]
Rolfs RT et al: A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. N Engl J Med 337:307, 1997 [PMID: 9235493]