Different Cell Death Mechanisms between Ischemic Core and Penumbra Regions after Cerebral Ischemia
- 최초 등록일
- 2012.07.09
- 최종 저작일
- 2012.06
- 7페이지/ MS 워드
- 가격 2,000원
소개글
brain ischemia (뇌허혈) 시에 core와 penumbra에서 일어나는 cell death 에 대해 비교하고 설명한 레포트 입니다.
목차
Intro
Major Features of Ischemic Cell Death
1. Cell death
2. Ratio
3. Time period
4. Blood Flow
5. Location
6. ATP
7. Ionic and metabolic changes
8. Free radicals
9. Cell death in the core of the focal lesion
Cell death in the penumbra of the focal lesion
10. Ischemic cell change
Reference
본문내용
Ischemic cell death involves a complex cascade of events in cerebral ischemia. This phenomenon arises from permanent or prolonged occlusion of a cerebral artery (5). When a focal ischemic stroke occurs, the core of brain tissue exposed to the dramatic blood flow reduction. This eventually causes to necrotic cell death. Around this necrotic core, there is a region of hypoperfused, electrically silent tissue receives enough blood flow to keep neurons alive. This zone, which is affected less severely by an ischemic stroke, is called “ischemic penumbra”. This is associated with a delayed death of neurons.
Ischemic cell death is initiated by an inhibition of oxidative phosphorylation, and creates an early maelstrom of activity (3). The causes of ischemic cell death include decreased pH, decreased ATP, and initiation of free radical production by the mitochondrial chain. Moreover, rapid depletion of energy after cerebral ischemia leads to a loss of membrane potential and depolarization of nerves (1). The secondary changes in ion and chemical concentration would be followed up. The ischemic insult in the brain has numerous pathophysiological consequences including excitotoxicity, DNA damage, and production of free radical.
The process of cell death has at least three major stages:
1) An early development of ionic and chemical changes
2) Result of activation of perpetrators
참고 자료
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