약리학 실습 랫트에 Enrofloxacin 투여 후 약동학적 해석
- 최초 등록일
- 2013.12.25
- 최종 저작일
- 2013.12
- 10페이지/
한컴오피스
- 가격 1,000원
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목차
1. 동물실험
2. 약리학 실험(Pharmacokinetic analysis)
3. Enrofloxacin 분석 결과
본문내용
동물실험
* 실험목표 : 실험동물에 약물을 투여(s.c.)하고 미정맥 채혈을 실시하여 시간별 혈중농도를 분석하여 pharmacokinetics의 기본적 실험법을 익힌다.
* 실험준비물 : 8주령 SD Rat (200g +/- ) Enrofloxacin 주사액, 1cc 주사기, 10cc 주사기, 알코올 솜, Rat 보정틀, 24G IV catheter, microtube, 원심분리기, 생리식염수, micropipette (1000㎕), pipette tip
-Background information-
Drug: Enrofloxacin(바이트릴) 25㎎/㎖
-Enrofloxain: Enrofloxacin is a fluoroquinolone antibiotic sold by the Bayer Corporation under the trade name Baytril. Enrofloxacin is currently FDA-approved for treatment of individual pets and domestic animals in the United States. In September 2005, the FDA withdrew approval of Baytril for use in water to treat flocks of poultry, as this practice was noted to promote the evolution of fluoroquinolone-resistant strains of the bacterium Campylobacter, a human pathogen. Fluoroquinolones such as ciprofloxacin are widely used in the treatment of human disease
* 실험과정 :
- 각 혈액샘플을 담을 tube를 두 개씩 ( whole blood용+serum용) 준비하여 labelling한다.
참고 자료
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