알쯔하이머

목차

1. Alzhimer’s disease(AD)?
2. Pathophysiology of AD
3. Diagnostic Criteria
4. Drug for AD

본문내용

Alzheimer’s diseases?
Alzhimer’s disease(AD) is the most common
neuro-degenerative disorder and most frequent cause of dementia in the eldery.
☞ 1907 Alois Alzheimer
☞ 치매를 일으키는 가장 흔한 퇴행성 뇌질환

Aging, the incidence of AD increase with age but is not consider a normal consequence of aging.

Pathophysiology of Alzheimer’s disease
AD is characterized by the presence of neurofibrillary tangles and senile plaques.
<Cause>
(1) Deposit of ß-amyloid protein
→ senile plaques. (신경반)
▶ the subject under investigation
(2) Hyperphosphorylated tau protein
→ neurofibrillary tangles (신경섬유다발)
▶ the subject under investigation

참고 자료

Basic & Clinical Pharmacology 12th edition (Bertam G. Katzung, Susan B. Masters, Anthony J.Trevor)
Pathophysiology (Carie A. Brown/ Cindy M. Anderson , 2010)
새로운 알츠하이머병 임상진단기준 : NIA-AA 진단가이드라인을 중심으로
서울대학교병원 정신건강의학과, 서울대학교 의과대학 정신과학교실 이 동 영·손 보 경
American Academy of Neurology : www.aan.com
Alzheimer’s Disease advocacy Group : www.alz.org
Caregiver Organizations : www.caregiver.org
Alzheimer’s Disease Education and Referral Center : www.alzheimer.org/adear
Ntional institute on Aging : www.nih.gov/nia
Agency for Toxic Substances and Disease Registry : http://www.atsdr.cdc.gov
CNSFORUM : www.cnsforum.com
CNS spectrum : www.cnsspectrums.com
대한치매학회 : http://www.dementia.or.kr
Dementia guide : http://www.dementiaguide.com
Anaesthesia UK : http://www.frca.co.uk
National Center for Biotechnology Information, U.S. National Library of Medicine : http://www.ncbi.nlm.nih.gov
WebMD : http://www.webmd.com
EPDA : http://www.epda.eu.com
www.nature.com
National Center for Biotechnology Information, U.S. National Library of Medicine : http://www.ncbi.nlm.nih.gov