Dyslipidemia 치료 2014년 가이드라인과 Apolipoprotein와 LDL 에 대한 원리 설명

목차

1. Part 1 Introduction
1) Lipid transport & Lipoprotein
2) Apolipoprotein

2. Part 2 Traditional indicator of CHD : LDL-C

3. Part 3 LDL-C vs non-HDL-C, LDL-P & Apo-B

4. Part 4 Guidelines of Dyslipidemia : What has changed

5. Part 5 Apo-B : Practical use & Summary

본문내용

Heterogeneity of LDL-particles : Not all LDL-particles the same
Small dense LDL (diameter <256A) vs Large buoyant LDL (diameter >256 A)
2057 men with High LDL, 5 year follow-up
Those with elevated small dense LDL had RR of 2.2 for IHD compared to men with elevated large buoyant LDL

<중 략>

** Friedewald formula
LDL cholesterol = total cholesterol – HDL cholesterol – (0.20 × lyceride) (mg/dL)
- Inaccurate when: TG high(>400 mg/dL) / Glucose high / LDL-C very low
Non-HDL: amount of cholesterol in atherogenic particles
LDL-P: Number of LDL particles
Apo-B: Number of Atherogenic particles
Normal range : M(63-133 mg/dL), F(60-126 mg/dL)

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