Mechanism of cancer 발표 자료

소개글

cancer의 mechanism에 대한 발표 자료입니다.
대학원 발표수업 자료로 최신 논문과 관련된 내용도 포함되어있습니다.

목차

1. Introduction
2. Chemotherapy strategies
3. Principle of tumor biology
4. Classification of chemotherapeutic agents
5. Novel therapies for the future
6. Conclusion
7. Reference

본문내용

Cell Cycle Non Specific Agent(CCNSA)
Many binds to cellular DNA.
Useful against low growth and high growth tumors. (e.g. colon, lung cancer)
Dose dependent.
Alkylating Agent – alter DNA. Nitrogen mustard, Busulfan
Cytotoxic antibiotics – DNA & RNA distort. Bleomycin
Platinum compounds
Natural products – binds to receptor sites that promote growth. Tomoxifen
Cell cycle에 specific하지 않은 것을 CCNSA라고 분류하고 있고, 이런 약들은 대부분 DNA에 binding하고 높거나 낮은 생장률의 암세포에서 모두 잘 적용됩니다. Alkylating agent, cytotoxic antibiotics, platinum compounds 등이 이에 해당됩니다.

참고 자료

Williams Gynecology
By John Schorge, Joseph Schaffer, Lisa Halvorson, Barbara Hoffman, Karen Bradshaw, and F. Cunningham. New York: McGraw Hill Medical, 2008. Chapter 27.
National Cancer Institute. https://www.cancer.gov/
Weiner, G. J. (2015). Building better monoclonal antibody-based therapeutics. Nature Reviews Cancer, 15(6), 361.
Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., ... & Cogdill, A. P. (2018). Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients. Science, 359(6371), 97-103.