타액에서 구강암 진단지표 발표자료, 서울대
- 최초 등록일
- 2018.12.21
- 최종 저작일
- 2018.12
- 15페이지/
MS 파워포인트
- 가격 8,000원
![할인쿠폰받기](/images/v4/document/ico_det_coupon.gif)
목차
1. Saliva-based analyses
2. Oxidative stress related molecules(OSRM)
3. Saliva antioxidant level
4. Oxidative damage
5. Saliva Nitrogen species
6. Detection method
7. Study results
8. Conclusions
본문내용
Saliva-based analyses
•Oral fluid sampling is simple
•Non-invasive
•Safe for both the operator and the patient
•Easy and low-cost storage
구강 플루이드는 샘플링이 쉽고 비침습적이며 환자와 술자에게 모두 안전합니다 또한 보관이 쉽고 저렴하게 보관이 가능합니다.
Oxidative stress related molecules(OSRM)
•Oxidative and nitrative stress contribute to the development of oral carcinogenesis from leukoplakia
•DNA damage
•Protein denaturation
•Lipid peroxidation
이 산화 스트레스 릴레이티브 분자
산화 와 질산화 자극의 경우 백반증에서 구강 발암을 야기할수 있습니다.
하이드록시 라디칼을 포함한 ROS의 경우
DNA 손상, 단백질 변성, 지질 과산화
참고 자료
Agha-Hosseini F, Mirzaii-Dizgah I, Mikaili S, Abdollahi M. Increased salivary lipid peroxidation in human subjects with oral lichen planus. Int J Dent Hyg 2009;7: 246–50.
Agha-Hosseini F, Mirzaii-Dizgah I, Rahimi A. Correlation of serum and salivary CA15-3 levels in patients with breast cancer. Med Oral Patol Oral Cir Bucal 2009;14:e521–4.
Halliwell,B., Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 1994;10:721-724.
Dreher,D.,Junod,AF., Role of oxygen free radicals in cancer development. Eur J Cancer 1996;32:30-38.
Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2’ -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2009; 27: 120–39.
Nagler RM, Klein I, Zarzhevsky N, Drigues N, Reznick AZ. Characterization of the differentiated antioxidant profile of human saliva. Free Radic Biol Med. 2002;32:268–277.
Sundberg AG, Appelkvist EL, Backman L, Dallner G. Quantitation of glutathione transferase-pi in the urine by radioimmunoassay. Nephron. 1994;66:162–169.
Fiddler RN. Collaborative study of modified AOAC method of analysis for nitrite in meat and meat products. J Assoc Off Anal Chem. 1977;60:594–599.
Bahar G, Feinmesser R, Shpitzer T, Popovtzer A, Nagler RM. Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile. Cancer. 2007;109:54-9.