[case review]응급의학과_DI
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- 2019.03.11
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- 2018.04
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목차
1. ACETAMINOPHEN TOXICITY
1) Background
2) Pathophysiology
3) Manifestation
4) Diagnostic Evaluation
5) Management
2. OPIOID TOXICITY
1) Background
2) Mechanism of Action
3) Pharmacokinetics
4) Manifestation
5) Diagnostic Evaluation
6) Management
3. ASPIRIN TOXICITY
1) Background
2) Pathophysiology
3) Effect on Aerobic Metabolism
4) Manifestation
5) Diagnostic Evaluation
6) Management
본문내용
1. ACETAMINOPHEN TOXICITY
[Background]
' First clinically used in 1955
' In USA: most commonly used antipyretic & analgesic medication
'In USA: most common cause of acute hepatic failure
[Pathophysiology]
' Act on the peroxidase binding site of PGE2, indirectly inhibit COX activation
' FDA recommended maximum daily
dose:
' ≥50kg: 4g
' <50kg: 75mg/kg
' Acute renal hepatotoxicity especially in underlying liver disease, chronic alcohol use, concomitant use of phenytoin and isoniazid, malnutrition, advanced age
참고 자료
Ciejka, M. et al. (2016). Drug toxicities of common analgesic medication in the emergency department. Clin Lab Med, 36(4): 761-776. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/27842792
Davies, J., Eddleston, M., & Buckley, N. (2008). Predicting outcome in acute organophosphorus poisoning with a poison severity score or the Glasgow coma scale. Q J Med, 101: 371-379. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493062/
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Tintinalli, 8th edition