Inhibition of Nogo: A key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system
- 최초 등록일
- 2007.02.21
- 최종 저작일
- 2007.01
- 14페이지/ MS 파워포인트
- 가격 2,000원
소개글
손상된 spinal cord의 재생을 억제 시키는 key factor인 nogo proteine에 관한 전반적인 특징과 nogo의 기능을 억제 시켜 손상된 신경으로 인해 유발된 여러 신경성 장애를 치료하고 재생 시키려는 다양한 전략들에 대한 정리
목차
Introduction
Nogo-A and its interaction partners
Spinal cord injury
Strategy
Effects of inactivation of Nogo-A on regeneration and axonal sprouting in vivo
Functional recovery after spinal cord injury and Nogo-A inactivation
Nogo antibodies in ischaemic stroke andtraumatic brain injury
Outlook
Terminology
본문내용
In the adult central nervous system (CNS) myelin and oligodendrocytes, Nogo-A exerts a growth inhibitory function
leading to restricted axonal regeneration. After development of different anti-Nogo-A antibodies and other Nogo-A
blocking reagents their application has recently been studied in various in vivo animal models of spinal cord injury and
stroke. These studies show that intracerebral application of Nogo-A-inactivating reagents leads to enhanced regeneration
and compensatory sprouting, structural reorganization or plasticity, and functional recovery as seen in different behavioural analyses.
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