[의학]위장관의 운동질환

소개글

위장관의 운동질환

목차

1. 위, 소장, 대장의 정상운동
2. 위장관 운동의 측정
3. 위장관 운동질환

본문내용

1. 위, 소장, 대장의 정상운동
control regional intraluminal pressure--movement of content

myoelectric activity : slow wave + spike potentials.
slow wave : cyclic change in membrane potential
spike potential : calcium influx -- sm cell contraction

propagating contraction
stomach : 위의 근육세포가 tightly electrical coupling되어 있어서 slow wave frequency에 변화 없이 propagate.
small, colon : pressure gradient>frequency gradient in contraction

circular m. : segment the lumen and mixing

longitudinal m. : shorten the bowel and moving

contraction of gastrointestinal sm : intracellular calcium증가
기전 : activated receptor at smc memb.--
inositol triphosphate produce--
Ca release from SR or calcium channel open--
intracellular Ca증가--
phosphorylation of myosin light chain--
actin-myosin cross-bridge formation--
increase in velosity of sm shortening.

relaxation of sm
cyclic AMP production
by ligand activation of receptor--
decrease intracellular calcium by calcium movement into SR or out of cell.

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