Sclerodema

소개글

Sclerodema 정리본

목차

CLASSIFICATION
EPIDEMIOLOGY
CLINICAL MANIFESTATIONS
CREST SYNDROME
MIXED CONNECTIVE TISSUE DISEASE
EOSINOPHILIC FASCITIS AND EOSINOPHILIA-MYALGIA SYNDROME
TOXIC OIL SYNDROME
CUTANEOUS HISTOPATHOLOGY
PATHOGNESIS
COURSE
METHOD

본문내용

* Definition
: chronic disease of unknown etiology
: affect microvasculature and loose connective tissue
: skin 과 다양한 내부장기에 fibrous deposition and obliteration of vessel을 특징

CLASSIFICATION
- localized scleroderma
: morphea
: generalized morphea
: guttate (variant of lichen sclerosus et atrophicus) morphea
: nodular (keloidal) morphea
: subcutaneous morhea (morphea profunda)
: linear scleroderma
- systemic scleroderma
: limited SSc (lSSc)
: diffuse SSc (dSSc)

EPIDEMIOLOGY
- localized morphea
: women > men (2.6:1)
: whites than in black
: between the ages of 20 and 50 (75%)
(linear scleroderma 는 age of onset is earlier)
- systemic sclerosis (SSc)
: women > men (4:1)
: black women 이 black men과 whites에 비해 유병율이 높다
: diffuse disease에서는 black 이 white보다 높다
: between the ages of 30 and 50
* classification of SSc into ISSc and dSSc 는 예후에 있어서 중요
: survival rate for 1, 6, and 12 years
dSSc) 80, 30, 15%
lSSc) 98, 80, 50%
: older patients가 예후가 안좋다
: women이 예후가 좋다

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