먹이섭취량, 지방생성과 성장의 돼지형질과 관 련된 후보유전자 Melanocortin – 4 Receptor(MC4-R)
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먹이섭취량, 지방생성과 성장의 돼지형질과 관 련된 후보유전자 Melanocortin – 4 Receptor(MC4-R)
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*Opinions
MC4R genotype was significantly associated with average daily gain, daily feed intake and ultrasonic backfat depth. (n=270) (R. D. Houston et al. 2004) .
MC4R alleles were associated with growth and fatness traits in Landrace, Large White and synthetic lines that had been generated by crossing LW and Duroc (Hernandez-Sanchez et al. 2003; Houston et al. 2004) .
The significant QTL for fat deposition traits on the MC4R locus of the Berkshire and Yorkshire intercross was found (n = 525) (Kim K-S et al) .
In contrast, studies on the porcine Large White · Wild Boar reference family did not reveal any significant affects of MC4R variants (Park et al. 2002; M. Stachowiak et al. 2005) .
The effect of the MC4R locus on growth or fatness traits in a small Wildboar by Large White intercross population was not found (n = 190) (Park et al. 2002) .
MC4R G/A was not associated with backfat thickness but it was significantly associated with average
참고 자료
Cone RD 1999 The central melanocortin system and energy homeostasis. Trends in Endocrinology and Metabolism 10 211–216.
C R Barb, A S Robertson, J B Barrett, R R Kraeling and K L Houseknecht 2004 The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig. Journal of Endocrinology 181, 39–52.
C. S. Bruun, C. B. Jørgensen, V. H. Nielsen, L. Andersson and M. Fredholm 2006 Evaluation of the porcine melanocortin 4 receptor (MC4R) gene as a positional candidate for a fatness QTL in a cross between Landrace and Hampshire International Society for Animal Genetics, Animal Genetics, 37, 359–362 359.
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