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Introduction- Significance and Background
- What is Alzheimer’s Disease?
Anti-Alzheimer’s Disease Effects of Curcumin
- Inhibitory Effects on Acetylcholinesterase (AchE)
- Protective activities against amyloid-beta (Aβ) peptide
Results & Discussion
References
본문내용
Statistics (Alzheimer’s Association, 2008)One in Eight Americans Over the Age of 65
One in Two of Americans Over the Age of 85
The Annual Economic Cost of AD Health Care
Expenses and Lost Wages Over
Around 2050, 16 Millions Elderly Population Will
Be Affected (= )
What is Alzheimer’s Disease?
$80-100 Billions
One Patient/ 33 sec
Table 1. Percent change in leading causes of death from 2000 to 2004 in U. S. (Centers for Disease Control and Prevention, 2004)
What is Alzheimer’s Disease?
Neurodegenerative Disorder Correlated with
- Cognitive Malfunction
- Loss of Memory
- Unusual Behavior and Declined Perception Ability
Major Pathological Changes in the Brains of AD
- Loss of Neurons
- Lowered Level of Neurotransmitter (AchE)
- Abnormal Protein Depositions (e.g. Senile Plaques)
Tumeric (Curcuma longa L.)
Tumeric has been used for
Natural Colorants
Medicinal Herb (Wound Healing, Inflammation, Asthma etc.)
Food Additives (Curry Spice)
Cosmetics (Sunscreens)
Curcumin is considered the major compound that responsible for these medicinal properties
www.taraexim.com/products.html
Protective Activity of Curcumin on Aβ*
참고 자료
Prasad, K.N., Hovland, A.R., Cole, W.C., Prasad, K.C., Nahreini, P., Edwards-Prasad, J., and Andreatta, C.P., Multiple antioxidants in the prevention and treatment of Alzheimer’s disease: analysis of biologic rationale. Clin. Neuropharmacol., 23, 2-13 (2000)2) Heo, H.J., Cho, H.Y., Hong, B.S., Kim, H.K., Kim, E.K., Kim, B.G., and Shin, D.H., Protective effect of 4`,5-dihydroxy-3`,6,7-trimethoxyflavone from Artemisia asiatica against Aβ -induced oxidative stress in PC12 cells. Amyloid., 8, 194-201 (2001)
3) Choi, S.J., Kim, M.J., Heo, H.J., Kim, H.K., Hong, B.S., Kim, C.J., Kim, B.G., and Shin, D.H. Protective effect of Rosa laevigata against amyloid beta peptide-induced oxidative stress. Amyloid., 13, 6-12 (2006)
5) Markesbery, W.R., and Carney, J.M., Oxidative alterations in Alzheimer`s disease. Brain Pathol., 9, 133-146 (1999)
6) Behl, C., Davis, J., Cole, G.M., and Schubert, D., Vitamin E protects nerve cells from amyloid β protein toxicity. Biochem. Biophys. Res. Commun., 186, 944-950 (1992)
7) Markesbery, W.R., and Lovell, M.A., DNA oxidation in Alzheimer`s disease. Antioxid. Redox. Signal., 8, 2039-2045 (2006)
8) Shin, E.J., Suh, S.K., Lim, Y.K., Jhoo, W.K., Hjelle, O.P., Ottersen, O.P., Shin, C.Y., Ko, K.H., Kim, W.K., Kim, D.S., Chun, W., Ali, S., and Kim, H.C., Ascorbate attenuates trimethyltin-induced oxidative burden and neuronal degeneration in the rat hippocampus by maintaining glutathione homeostasis. Neuroscience, 133, 715-727 (2005)
9) Behl, C., Vitamin E and other antioxidants in neuroprotection. Int. J. Vitam. Nutr. Res., 69, 213-219 (1999)
10) Behl, C., Amyloid β -protein toxicity and oxidative stress in Alzheimer`s disease. Cell Tissue Res., 290, 471-480 (1997)
